Immunohistochemical Characterization of Hyaline Globules in Kaposi’s Sarcoma
Identifieur interne : 008354 ( Main/Exploration ); précédent : 008353; suivant : 008355Immunohistochemical Characterization of Hyaline Globules in Kaposi’s Sarcoma
Auteurs : N. Gupta [États-Unis] ; K. Inamdar [États-Unis] ; M. Chaffins [États-Unis] ; C. Ma [États-Unis] ; A. Ormsby [États-Unis] ; M. Lee [États-Unis]Source :
- Journal of Cutaneous Pathology [ 0303-6987 ] ; 2005-01.
Abstract
Hyaline globules (HG) are frequently found in neoplastic cells of Kaposi’s sarcoma (KS). Presence of HG, characteristic of but not specific of KS, has been considered to represent erythrophagocytosis. In order to further characterize the nature of HG, we studied 10 cases of cutaneous KS with distinct HG using immunohistochemistry for hemoglobin A, Kappa and Lambda. All KS cases were of nodular type. Also included were 3 cases of glomeruloid hemangioma with similar HG in endothelial cells for the comparision. In selected cases electron microscopic examination was performed. PAS stain with diastase digestion was also done in all cases. Results: HG were diastase resistant and PAS positive. All HG in neoplastic cells of KS and endothelial cells of GH were negative for hemoglobin A. There was variable staining for light chains: focal but strong positivity for kappa, weak and variable staining for Lambda. Some HG was positive for both kappa and lambda. Electron microscopic study demonstrated HG as homogeneous electron dense inclusions with internal small vacuoles, whorled or granular materials. Conclusions: All HG in neoplastic cells and endothelial cells of GH represent phagolysosomes. Negative stain for hemoglobin A in KS and GH do not support the inclusions being fragmented RBC’s.
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DOI: 10.1111/j.0303-6987.2005.320cj.x
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Gupta</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Dermatology, Henry Ford Hospital, Detroit, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Inamdar, K" sort="Inamdar, K" uniqKey="Inamdar K" first="K." last="Inamdar">K. Inamdar</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Dermatology, Henry Ford Hospital, Detroit, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Chaffins, M" sort="Chaffins, M" uniqKey="Chaffins M" first="M." last="Chaffins">M. Chaffins</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Dermatology, Henry Ford Hospital, Detroit, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Ma, C" sort="Ma, C" uniqKey="Ma C" first="C." last="Ma">C. Ma</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Dermatology, Henry Ford Hospital, Detroit, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Ormsby, A" sort="Ormsby, A" uniqKey="Ormsby A" first="A." last="Ormsby">A. Ormsby</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Dermatology, Henry Ford Hospital, Detroit, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author><author><name sortKey="Lee, M" sort="Lee, M" uniqKey="Lee M" first="M." last="Lee">M. Lee</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology and Dermatology, Henry Ford Hospital, Detroit, MI</wicri:regionArea><placeName><region type="state">Michigan</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Cutaneous Pathology</title><title level="j" type="alt">JOURNAL OF CUTANEOUS PATHOLOGY</title><idno type="ISSN">0303-6987</idno><idno type="eISSN">1600-0560</idno><imprint><biblScope unit="vol">32</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="90">90</biblScope><biblScope unit="page" to="90">90</biblScope><biblScope unit="page-count">1</biblScope><publisher>Blackwell Publishing Ltd/Inc.</publisher><pubPlace>Oxford, UK; Malden, USA</pubPlace><date type="published" when="2005-01">2005-01</date></imprint><idno type="ISSN">0303-6987</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0303-6987</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Hyaline globules (HG) are frequently found in neoplastic cells of Kaposi’s sarcoma (KS). Presence of HG, characteristic of but not specific of KS, has been considered to represent erythrophagocytosis. In order to further characterize the nature of HG, we studied 10 cases of cutaneous KS with distinct HG using immunohistochemistry for hemoglobin A, Kappa and Lambda. All KS cases were of nodular type. Also included were 3 cases of glomeruloid hemangioma with similar HG in endothelial cells for the comparision. In selected cases electron microscopic examination was performed. PAS stain with diastase digestion was also done in all cases. Results: HG were diastase resistant and PAS positive. All HG in neoplastic cells of KS and endothelial cells of GH were negative for hemoglobin A. There was variable staining for light chains: focal but strong positivity for kappa, weak and variable staining for Lambda. Some HG was positive for both kappa and lambda. Electron microscopic study demonstrated HG as homogeneous electron dense inclusions with internal small vacuoles, whorled or granular materials. Conclusions: All HG in neoplastic cells and endothelial cells of GH represent phagolysosomes. Negative stain for hemoglobin A in KS and GH do not support the inclusions being fragmented RBC’s.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Michigan</li></region></list><tree><country name="États-Unis"><region name="Michigan"><name sortKey="Gupta, N" sort="Gupta, N" uniqKey="Gupta N" first="N." last="Gupta">N. Gupta</name></region><name sortKey="Chaffins, M" sort="Chaffins, M" uniqKey="Chaffins M" first="M." last="Chaffins">M. Chaffins</name><name sortKey="Inamdar, K" sort="Inamdar, K" uniqKey="Inamdar K" first="K." last="Inamdar">K. Inamdar</name><name sortKey="Lee, M" sort="Lee, M" uniqKey="Lee M" first="M." last="Lee">M. Lee</name><name sortKey="Ma, C" sort="Ma, C" uniqKey="Ma C" first="C." last="Ma">C. Ma</name><name sortKey="Ormsby, A" sort="Ormsby, A" uniqKey="Ormsby A" first="A." last="Ormsby">A. Ormsby</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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